![]() Pregnancy category: C (US FDA), D (AU TGA) RARα forms heterodimers with RXR and binds to retinoic acid response elements that are present in genes involved in cell differentiation.Īgain, like topical tretinoin, the exact mechanism of systemic tretinoin is unclear but is hypothesized to include the following:Īccording to FDA labeled drug guidelines, contraindications include patients with evidence of hypersensitivity to tretinoin or any of its components. Retinoic acid binds to retinoic acid receptor alpha, a member of the steroid-thyroid hormone receptor superfamily. RAR-alpha and -beta has presented in associated with APL and squamous cell malignancies, respectively. By doing so, the comedo contents can be expelled, with a reduction of microcomedo precursor lesion of acne vulgaris. Tretinoin increases mitotic activity, thereby increasing loosely-adherent corneocytes turnover. Tretinoin's effectiveness as an acne medication is because of its ability to modify the abnormal follicular formation that comes from excessive keratinization of epithelial cells. Tretinoin promotes cornified cell detachment and enhances shedding. RAR-gamma effects are associated with mucocutaneous tissues and bone. ![]() By doing this, the production of procollagen increases to augment collagen type I and III formations. The exact mechanism by which topical tretinoin functions are not completely understood, but current evidence suggests mediation through binding of retinoic acid receptors (RARs) alpha, beta, and gamma along with retinoid X receptors (RXRs) by blocking inflammatory mediators. This activity will highlight the mechanism of action, adverse event profile, and other key factors such as off-label uses, including some indications of APL, pre-malignant and malignant skin conditions, and other common skin conditions such as psoriasis, dosing of both oral and topical treatment options, monitoring of both topical and oral tretinoin use (i.e., with emphasis on reliable contraception) pertinent for members of the interprofessional team and healthcare team in the treatment of mild, moderate, severe acne and acute promyelocytic leukemia and related conditions. This activity outlines and reviews the indications, actions, and contraindications of tretinoin as a valuable agent in treating acne vulgaris and APL management and therapy. Tretinoin is a vitamin A derivate in the retinoids class of medications. Tretinoin is also used systemically in the management of acute promyelocytic leukemia (APL). We recommend going for tretinoin cream to be safe from higher degrees of skin irritation and dryness.Tretinoin is a valuable medication in treating mild, moderate, and severe acne that can be used topically or systemically. Wrapping the retin a gel vs cream debate up, it can be said that tretinoin gel and tretinoin cream are both essential skincare medications when it comes to combating skin conditions.īoth have good treating properties in case of acne, sun damage, and fine lines, but tretinoin cream is/has a more appropriate formulation compared to tretinoin gel. ![]() Tretinoin cream has a slower working ability, is relatively gentle on the skin, and causes less dryness and flakiness.Tretinoin gel works quicker, has more chances of irritating the skin, and causes more flaky skin.Both the tretinoin gel and the cream cause drying of the skin however, the dryness is more pronounced with the gel formulation.Tretinoin gel and tretinoin cream are both enriched with vitamin A to treat a wide range of skin conditions like acne, fine lines, and sun damage.Absorption Tretinoin gel absorbs quickly Tretinoin cream takes some time to absorb Side Effects Tretinoin gel has more skin-irritating effects Tretinoin cream has relatively fewer skin irritation effects 6. Mode of Action Tretinoin gel works quickly Tretinoin creams work at a slower pace 5. Skin Suitability Tretinoin gel is suitable for very oily and acne-prone skin Tretinoin cream is suitable for all skin types, especially dry, mature, and sensitive skin 4. Dryness Tretinoin gel causes more dryness and flakiness of skin Tretinoin cream has a lower drying effect 3. Alcohol Content Tretinoin gel has higher alcohol content, which is responsible for a higher degree of side effects Tretinoin cream has a relatively lower alcohol content, which results in fewer side effects 2. Retin A Gel vs Cream: A Comparison Table Parameters of Comparison Tretinoin Gel Tretinoin Cream 1. Tretinoin cream does not cause any additional skin dryness and is ideal for almost all skin types.Tretinoin gel causes higher skin irritation and causes more dryness of the skin. ![]() Tretinoin cream has a thicker consistency and takes time to absorb and deliver the best results.Tretinoin gel is of a sheer consistency that works at a rapid action and absorbs fast.Main Differences Between Tretinoin Gel and Cream
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